Thalassemia with jaundice

At this momont, we have two patients of thalassemia with jaundice. Both are male, age 7 yrs, both are from poor socioeconomic class and both are thalassemia intermedia.
The first case has taken blood transfusion 1 year back, the second case was on hydroxyurea.
Both are HBsAg negative.
The first one develops jaundice due to acute hepatitis-nonB virus.In second the jaundice is induced by the hepatoxicity of the hydroxyurea.